summary:
. I get urgent bathroom calls from simply
the recommended amounts of fiber;
and, Loperamide was recommended
to harden the too-soft stools of IBS;
so, I investigated its addictiveness: very;
I found it is also an abusable opiate .
wiki`Loperamide
. it's good for irritable bowel syndrome,
not useful in preventing traveler's diarrhea;
on the World Health Organization's
List of Essential Medicines,
a list of the most important medication
needed in a basic health system.
. Loperamide treatment is not used in symptomatic
C. difficile infections,
as it increases the risk of toxin retention
and precipitation of toxic megacolon.
Loperamide should be administered with caution to
patients suffering from hepatic impairment
due to reduced first pass metabolism;
[many foods and drugs impair liver]
The four primary systems that affect
the first pass effect of a drug
are the enzymes of the gastrointestinal lumen
[interior from eg, the pancreas]
gut wall enzymes, bacterial enzymes, and hepatic enzymes.
madmargaret 2014/01`withdrawal is terrible:
A number of people who have survived the overdose
have purportedly been hospitalized due to cardiac events
(ventricular tachycardia leading to cardiac arrest).
.
. during loperamide 80 pill-a-day habit withdrawal,
you will feel all or most of the following at some point:
Early symptoms:Agitation, Anxiety, Muscle aches,
Insomnia
Sweating, Yawning
Late symptoms:Abdominal cramping, Diarrhea
Dilated pupils, Goose bumps
Nausea, Vomiting
-- withdrawal from loperamide was much worse overall
than other ‘traditional’ opiates.
even when going from 6 per day to zero
withdrawal syndrome was only slightly milder .
.
Get a good quality toilet paper
and indulge in some flushable wipes — lots of them.
The minute you think you have to go, GO.
Don’t try to be a hero.
Dietary changes (eat more cheese, for instance)
will help a little
.
I take 100mg of hydroxyzene for sleep, even now.
You might also want to try taking
magnesium which can help to ease some of the
electric zaps and RLS [Restless Legs Syndrome] symptoms
caused by the newly-raw calcium channels on the nerve endings.
(Also protects your heart!)
drugs-forum.com:
. you can get Lope to cross the blood brain barrier
and get an opiate high,
you just need P-gp inhibitors that'll help it cross.
list of P-gp inhibitors
progesterone
other inhibitors:
Piperine
Quercetin
Quinidine
Quinine
--
St John’s wort is a P-gp inducer
opiophile.org:
. tonic water has quinine in it;springerlink.com`demethylating loperamide:
Do NOT eat before or after taking lope for a few hours.
--
cimetidine [ histamine H2-receptor antagonist
that inhibits stomach acid production]
inhibits the enzymes that metabolize loperamide so quickly
and it reduces acid secretion, it raises your gastric pH,
which affects p-Glycoprotein efflux.
--
I took a huge dose of loperamide with a real pGp inhibitor once,
and now I have this permanent parkinsonian jaw tremor;
Loperamide DOES form a neurotoxic metabolite, called LPP+
similar to the MPTP metabolite that causes instant parkinsons disease.
. the cytochrome P450 (P450) isoform(s)
involved in the metabolism of loperamide (LOP)
to N-demethylated LOP (DLOP) in human liver microsome .
. CYP2B6, CYP2C8, CYP2D6, and CYP3A4
catalyze LOP N-demethylation in human liver microsomes,
and among them, CYP2C8 and CYP3A4 may play a crucial role
in LOP metabolism at the therapeutic concentrations of LOP.
Coadministration of these P450 inhibitors may cause
drug interactions with LOP.
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